Research Tools

ResQ Biotech has developed the specialized Escherichia coli strains SuptoxD and SuptoxR for high-level production of difficult-to-express integral membrane proteins.

When used as expression hosts, these strains exert a dual positive effect on recombinant membrane protein production compared to wild-type bacteria:

(1) they suppress the toxicity that frequently accompanies the membrane protein overexpression process, thus enabling enhanced levels of final bacterial biomass, and

(2) they markedly increase the cellular accumulation of membrane-incorporated and properly folded protein.

Combined, these two positive effects result in dramatically enhanced volumetric yields for various recombinant membrane proteins of both prokaryotic and eukaryotic origin.

Stadiou, Platani, Rio, Patra 265 04, Greece

  • LinkedIn

©2019 by ResQ Biotech.